Despite modern life, man is still faced with mental, physical and mental pressures. Despite all the beauty and possessions, he still finds himself trapped and captive and has sought inner peace, true happiness and real hope. Therefore, man has paid attention to spirituality, which is a natural thing. Scientific research has proven that a more spiritual person is happier and more confident in his life. And he has reached peace. Islamic spirituality considers human happiness to be worthy and deserving of reaching divine proximity, and introduces man as having the talent for divine caliphate and the manifestation of divine names and attributes. The methods that Islam uses for spirituality are rooted and based on Sharia, which includes the Quran and Sunnah. One of them is the method of prayer and supplication, which is the most important function of prayer in the mysticism of the alluring unity that occurs through heartfelt remembrance. Mystical prayers are based on the principle of meditation and focusing on the soul. The prayers of the Imams (a.s.) are full of spiritual passion and excitement, with mystical references. Islamic prayers are a treasure trove of knowledge, including the prayers of Sha’baniyah, Kumail, and Arafat, the prayers of Abu Hamzah Thumali, and the prayers of Sahifa al-Sajjadiyah by Imam Sajjad, which are inspiring and highly informative. Therefore, the present study aims to examine the impact of spirituality in the areas of individual life from the perspective of Abu Hamzah Thumali’s prayers. In terms of the research method, it is descriptive and analytical, and the documentary, library, and Internet methods have been used to collect information in this article. The results of this study can be used in the field of peace, happiness, and hope for an individual from the prayers specific to Abu Hamzah Thumali’s prayers.