Irfan means knowing. In the term, the phrase is a state of knowledge that is obtained through the concentration of inner and self; which cannot be grasped through sense and reason; Rather, he achieved this knowledge and revelation through the process of conduct, these revelations and observations are the truth without any intermediary. Those who have been able to achieve this knowledge are called mystics. The root of this is in the book, the tradition and the holy texts of Sari. This research is trying to answer which aspects of mysticism in Shiism and Orthodox Christianity are common and in which cases are they different from each other? The purpose of this research is to discover the common points and differences of this issue in these two religions. This research has proved the common points and differences of mysticism in these two religions from the analytical and descriptive method to the library research method. Mysticism in these two religions is similar in some cases and different in some cases according to documents, writings and traditions. By exploring and according to documents and scriptures; Mysticism has a special place in these two religions. In Shiism, mysticism is the same as this religion, and in Orthodoxy, all human beings are considered to be in the shadow of mysticism.